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REFERENCES:

1. Cox L. Sublingual immunotherapy in pediatric allergic rhinitis and asthma: efficacy, safety, and practical considerations. Curr Allergy Asthma Rep. 2007 Nov;7(6):410-20.

 

2. penagos M, Passalacqua G, Compalati E, Baena-Cagnani CE, Orozco S, Pedroza A, Walter Canonica G. Meta-analysis of the efficacy of sublingual immunotherapy in the treatment of allergic asthma in pediatric patients, 3 to 18 years of age. Chest. 2007 Oct 20.

 

3. Greenberger PA, Ballow M, Casale TB, Platts-Mills TA, Sampson HA. Sublingual immunotherapy and subcutaneous immunotherapy: Issues in the United States. J Allergy Clin Immuno!. 2007 Oct 1.

 

4. Didier A, Mailing HJ, Worm M, Horak F, Jager S, Montagut A, Andre C, de Beaumont 0, Melac M. Optimal dose, efficacy, and safety of once-daily sublingual immunotherapy with a 5-grass pollen tablet for seasonal allergic rhinitis. J Allergy Clin Immuno!. 2007 Oct 10.

 

5. Saporta D, McDaniel AB. Efficacy comparison of multiple-antigen subcutaneous injection immunotherapy and multiple-antigen sublingual immunotherapy. Ear Nose Throat J. 2007 Aug;86(8):493-7.

 

6. Andre C, Fadel R. Anaphylaxis caused by allergen sublingual immunotherapy? Allergy. 2007 Oct;62(10):1220-1.

 

7. Cadario G, Galluccio AG, Pezza M, Appino A, Milani M, Pecora S, Mastrandrea F. Sublingual immunotherapy efficacy in patients with atopic dermatitis and house dust mites sensitivity: a prospective pilot study. Curr Med Res Opin. 2007 Oct;2l(10):2503-6.

 

8. Frew AJ. How does sublingual immunotherapy work? J tllergy Clin Immuno!. 2007 Sep;120(3):533-6.

 

9. Garcia-Marcos L, Lucas Moreno JM, Garde JG. subling_al specific immunotherapy: state of the art.  Inflamm Allergy Drug Targets. 2007 Jun;6(2): 117 -26.

 

10. Bohle B, Kinaciyan T, Gerstmayr M, Radakovics A, Jahn-Schmid B, Ebner C. Sublingual immunotherapy induces IL-10-producing T regulatory cells, allergen-specific T-cell tolerance, and immune deviation. J Allergy Clin Immuno!. 2007 Sep;120(3):707-13.

 

11. Ibanez MD, Kaiser F, Knecht R, Armentia A, Schopfer H, Tholstrup B, Bufe A. Safety of specific sublingual immunotherapy with sa standardized grass allergen tablets in children. Pediatr Allergy Immuno!. 2007 Sep;18(6):516-22.

 

12. Ozdemir C, Yazi D, Gocmen I, Yesil 0, Aydogan M, Semic-Jusufagic A, Bahceciler NN, Barlan lB. Efficacy of long-term sublingual immunotherapy as an adjunct to pharmacotherapy in house dust mite-allergic children with asthma. Pediatr Allergy Immuno!. 2007 Sep;18(6):508-15.

 

13. Calderon MA, Birk AO, Andersen JS, Durham SR. Prolonged preseasonal treatment phase with Grazax sublingual immunotherapy increases clinical efficacy. Allergy. 2007 Aug;62(8):958-61.

 

14. Durham SR, Riis B. Grass allergen tablet immunotherapy relieves individual seasonal eye and nasal symptoms, including nasal blockage. Allergy. 2007 Aug;62(8):954-7.

 

15. Alvarez-Cuesta E, Berges-Gimeno P, Gonzalez-Mancebo E, Fernandez-Caldas E, Cuesta-Herranz J, Casanovas M. Sublingual immunotherapy with a standardized cat dander extract: evaluation of efficacy in a double blind placebo controlled study. Allergy. 2007 Jul;62(7):810-7.

 

16. Mauroa M, Russelloa M, Incorvaiab C, Gazzolaa GB, Di Carac G, Frati F. Comparison of efficacy, safety and immunologic effects of subcutaneous and sublingual immunotherapy in birch pollinosis: a ran,domized study. Allerg Immunol (Paris). 2007 Apr;39(4):119-22.

 

17. Marcucci F, Sensi L, Allocca G, Chiarello F, Palleri P, Ugolini E, Di Rienzo A, Castellani S, Incorvaia C, Di Cara G, Puccinelli P, Frati F. Sublingual immunotherapy: from safety to mechanism of action. Allerg Immunol (Paris). 2007 Mar;39(3):101-3.

 

18. Kildsgaard J, Brimnes J, Jacobi H, Lund K. Sublingual immunotherapy in sensitized mice. Ann Allergy Asthma Immuno!. 2007 Apr;98(4):366-72.

 

19. Bachert C, Vestenbaek U, Christensen J, Griffiths UK, Poulsen PB. Cost-effectiveness of grass allergen tablet (GRAZAX) for the prevention of seasonal grass pollen induced rhinoconjunctivitis - a Northern European perspective. Clin Exp Allergy. 2007 May;37(5):772-9.

 

20. Passalacqua G, Durham SR; Global Allergy and Asthma European Network. Allergic rhinitis and its impact on asthma update: allergen immunotherapy. J Allergy Clin Immuno!. 2007 Apr;119(4):881-91.

 

21. Marogna M, Spadolini I, Massolo A, Zanon P, Berra D, Chiodini E, Canonica WG, Passalacqua G. Effects of sublingual immunotherapy for multiple or single allergens in polysensitized patients. Ann Allergy Asthma Immuno!. 2007 Mar;98(3):274-80.

 

22. Leatherman BD, Owen S, Parker M, Chadwick S, Fornadley JA, Colson D, Fass P. Sublingual Immunotherapy: Past, present, paradigm for the future? A review of the literature. Otolaryngol Head Neck Surg. 2007 Mar;136(3 Suppl):S1-20.

 

23. Eifan AO, Keles S, Bahceciler NN, Barlan lB. Anaphylaxis to multiple pollen allergen sublingual immunotherapy. Allergy. 2007 May;62(5):567-8. Epub 2007 Feb 20.

 

24. Passalacqua G, Musarra A, Pecora S, Amoroso S, Antonicelli L, Cadario G, Gioacchino MD, Lombardi C, Ridolo E, Sacerdoti G, Schiavino D, Senna G. Quantitative assessment of the compliance with once-daily sublingual immunotherapy in children (EASY project: evaluation of a novel SLIT formulation during a year). Pediatr Allergy Immuno!. 2007 Feb;18(1):58-62.

 

25. van Ree R. Indoor allergens: relevance of major allergen measurements and standardization. J Allergy Clin Immuno!. 2007 Feb;119(2):270-7; quiz 278-9. Epub 2006 Dec 12.

 

26. Calderon M, Essendrop M. Specific immunotherapy with high dose SQ standardized grass allergen tablets was safe and well tolerated. J Investig Allergol Clin Immuno!. 2006;16(6):338-44.

 

27. Vervloet D, Birnbaum J, Laurent P, Hugues B, Fardeau MF, Massabie-Bouchat YP, Aferiat-Derome A, Andre C. Safety and efficacy of Juniperus ashei sublingual-swallow ultra-rush pollen immunotherapy in cypress rhinoconjunctivitis. A double-blind, placebo-controlled study. Int Arch Allergy Immuno!. 2007;142(3):239-46. Epub 2006 Nov 15.

 

28. Passalacqua G, Canonica GW. Sublingual immunotherapy: update 2006. Curr Opin Allergy Clin Immuno!. 2006 Dec;6(6):449-54. Review.

 

29. Rak S, Yang WH, Pedersen MR, Durham SR. Once-daily sublingual allergen-specific immunotherapy improves quality of life in patients with grass pollen-induced allergic rhinoconjunctivitis: a double­blind, randomised study. Qual Life Res. 2007 Mar;16(2):191-201.

 

30. Bachert C. Comparison of solutions for sublingual immunotherapy. Int Arch Allergy Immuno!. 2007;142(1):89-90. Epub 2006 Oct 3.

 

31. Dunsky EH, Goldstein MF, Dvorin DJ, Belecanech GA. Anaphylaxis to sublingual immunotherapy. Allergy. 2006 Oct;61(10):1235.

 

32. Valovirta E, Jacobsen L, Lj0rring C, Koivikko A, Savolainen J. Clinical efficacy and safety of sublingual immunotherapy with tree pollen extract in children. Allergy. 2006 Oct;61(10):1177-83.

 

33. Calamita Z, Saconato H, Pela AB, Atallah AN. Efficacy of sublingual immunotherapy in asthma: systematic review of randomized-clinical trials using the Cochrane Collaboration method. Allergy. 2006 Oct;61(10):1162-72. Review.

 

34. penagos M, Compalati E, Tarantini F, Baena-Cagnani R, Huerta J, Passalacqua G, Canonica GW. Efficacy of sublingual immunotherapy in the treatment of allergic rhinitis in pediatric patients 3 to 18 years of age: a meta-analysis of randomized, placebo-controlled, double-blind trials. Ann Allergy Asthma Immuno!. 2006 Aug;97(2):141-8.

 

35. Fernandez-Caldas E, Iraola V, Boquete M, Nieto A, Casanovas M. Mite immunotherapy. Curr Allergy Asthma Rep. 2006 Sep;6(5):413-9. Review.

 

36. Akdis CA, Barlan IB, Bahceciler N, Akdis M. Immunological mechanisms of sublingual immunotherapy. Allergy. 2006;61 Suppl 81 :11-4. Review.

 

37. Ortolani C, Agostinis F, Amoroso S, Ariano R, Barbato A, Bassi M, Cadario G, Campi P, Cardinale F, Ciprandi G, D'Anneo R, Di Gioacchino M, Di Rienzo V, Fiocchi A, Galimberti M, Galli E, Giovannini M, Incorvaia C, La Grutta S, Lombardi C, Marcucci F, Marseglia G, Minelli M, Musarra A, Nettis E, Novembre E, Pajno G, Patriarca G, Pezzuto F, Piras P, Pucci S, Romano A, Romano C, Quercia 0, Scala G, Schiavino D, Senna G, Sforza G, Tosca M, Tripodi S, Frati F. Practice parameters for sublingual immunotherapy. Monaldi Arch Chest Dis. 2006 Mar;65(1):44-6.

 

38. Cox LS, Linnemann DL, Nolte H, Weldon D, Finegold I, Nelson HS. Sublingual immunotherapy: a comprehensive review. J Allergy Clin Immuno!. 2006 May;117(5):1021-35.

 

39. Dahl R, Stender A, Rak S. Specific immunotherapy with SQ standardized grass allergen tablets in asthmatics with rhinoconjunctivitis. Allergy. 2006 Feb;61 (2): 185-90.

 

40.  Malling HJ. Comparison of the clinical efficacy and safety of subcutaneous and sublingual immunotherapy: methodological approaches and experimental results. Curr Opin Allergy Clin Immunol. 2004; 4(6): 539-42.

 

41.  Fiocchi A, Pajno G, La Grutta S, Pezzuto F, Incorvaia C, Sensi L, Marcucci F, Frati F. Safety of sublingual-swallow immunotherapy in children aged 3 to 7 years. Ann Allergy Asthma Immunol. 2005 Sep;95(3):254-8.

 

42.  Marcucci F, Sensi L, Di Cara G, Salvatori S, Bernini M, Pecora S, Burastero SE. Three-year follow-up of clinical and inflammation parameters in children monosensitized to mites undergoing sub-lingual immunotherapy. Pediatr Allergy Immunol. 2005 Sep;16(6):519-26.

 

43.  Marogna M, Spadolini I, Massolo A, Canonica GW, Passalacqua G. Clinical, functional, and immunologic effects of sublingual immunotherapy in birch pollinosis: a 3-year randomized controlled study. J Allergy Clin Immunol. 2005 Jun;115(6):1184-8.

 

44.  Gidaro GB, Marcucci F, Sensi L, Incorvaia C, Frati F, Ciprandi G. The safety of sublingual-swallow immunotherapy: an analysis of published studies. Clin Exp Allergy. 2005 May;35(5):565-71.

 

45. Rienzo VD, Minelli M, Musarra A, Sambugaro R, Pecora S, Canonica WG, Passalacqua G. Post-marketing survey on the safety of sublingual immunotherapy in children below the age of 5 years.Clin Exp Allergy. 2005 May;35(5):560-4.

 

46.  Bahceciler NN, Arikan C, Taylor A, Akdis M, Blaser K, Barlan IB, Akdis CA. Impact of sublingual immunotherapy on specific antibody levels in asthmatic children allergic to house dust mites. Int Arch Allergy Immunol. 2005 Mar;136(3):287-94.

 

47. Wilson DR, Lima MT, Durham SR. Sublingual immunotherapy for allergic rhinitis: systematic review and meta-analysis. Allergy. 2005 Jan;60(1):4-12. Review.

 

48.  Rolinck-Werninghaus C, Wolf H, Liebke C, Baars JC, Lange J, Kopp MV, Hammermann J, Leupold W, Bartels P, Gruebl A, Bauer CP, Schnitker J, Wahn U, Niggemann B. A prospective, randomized, double-blind, placebo controlled multi-centre study on the efficacy and safety of sublingual immunotherapy (SLIT) in children with seasonal allergic rhinoconjunctivitis to grass pollen. Allergy. 2004 Dec;59(12):1285-93.

 

49. Novembre E, Galli E, Landi F, Caffarelli C, Pifferi M, De Marco E, Burastero SE, Calori G, Benetti L, Bonazza P, Puccinelli P, Parmiani S, Bernardini R, Vierucci A. Coseasonal sublingual immunotherapy reduces the development of asthma in children with allergic rhinoconjunctivitis. J Allergy Clin Immunol. 2004 Oct;114(4):851-7.

 

50. Smith H, White P, Annila I, Poole J, Andre C, Frew A. Randomized controlled trial of high-dose sublingual immunotherapy to treat seasonal allergic rhinitis. J Allergy Clin Immunol. 2004 Oct;114(4):831-7.

 

51. Canonica GW, Compalati E, Fumagalli F, Passalacqua G. Sublingual and oral immunotherapy. Immunol Allergy Clin North Am. 2004 Nov;24(4):685-704, vii.

 

52. Passalacqua G, Guerra L, Pasquali M, Lombardi C, Canonica GW. Efficacy and safety of sublingual immunotherapy. Ann Allergy Asthma Immunol. 2004 Jul;93(1):3-12.

 

53. Pajno GB, Passalacqua G, Vita D, Caminiti L, Parmiani S, Barberio G. Sublingual immunotherapy abrogates seasonal bronchial hyperresponsiveness in children with Parietaria-induced respiratory allergy: a randomized controlled trial. Allergy. 2004 Aug;59(8):883-7.

 

54. Sopo SM, Macchiaiolo M, Zorzi G, Tripodi S. Sublingual immunotherapy in asthma and rhinoconjunctivitis; systematic review of paediatric literature. Arch Dis Child. 2004 Jul;89(7):620-4. Review.

 

55. Bufe A, Ziegler-Kirbach E, Stoeckmann E, Heidemann P, Gehlhar K, Holland-Letz T, Braun W. Efficacy of sublingual swallow immunotherapy in children with severe grass pollen allergic symptoms: a double-blind placebo-controlled study. Allergy. 2004 May;59(5):498-504.

 

56. Tonnel AB, Scherpereel A, Douay B, Mellin B, Leprince D, Goldstein N, Delecluse P, Andre C. Allergic rhinitis due to house dust mites: evaluation of the efficacy of specific sublingual immunotherapy. Allergy. 2004 May;59(5):491-7.

 

57. Khinchi MS, Poulsen LK, Carat F, Andre C, Hansen AB, Malling HJ. Clinical efficacy of sublingual and subcutaneous birch pollen allergen-specific immunotherapy: a randomized, placebo-controlled, double-blind, double-dummy study. Allergy. 2004 Jan;59(1):45-53.

 

58. Wuthrich B, Bucher Ch, Jorg W, Bircher A, Eng P, Schneider Y, Schnyder F Eigenmann P, Senti G. Double-blind, placebo-controlled study with sublingual immunotherapy in children with seasonal allergic rhinitis to grass pollen. J Investig Allergol Clin Immunol. 2003;13(3):145-8.

 

59. Wilson DR, Torres LI, Durham SR. Sublingual immunotherapy for allergic rhinitis. Cochrane Database Syst Rev. 2003;(2):CD002893. Review.

 

60. Mortemousque B, Bertel F, De Casamayor J, Verin P, Colin J. House-dust mite sublingual-swallow immunotherapy in perennial conjunctivitis: a double-blind, placebo-controlled study. Clin Exp Allergy. 2003 Apr;33(4):464-9.

 

61. Di Rienzo V, Marcucci F, Puccinelli P, Parmiani S, Frati F, Sensi L, Canonica GW, Passalacqua G. Long-lasting effect of sublingual immunotherapy in children with asthma due to house dust mite: a 10-year prospective study. Clin Exp Allergy. 2003 Feb;33(2):206-10.

 

62. Lima MT, Wilson D, Pitkin L, Roberts A, Nouri-Aria K, Jacobson M, Walker S, Durham S. Grass pollen sublingual immunotherapy for seasonal rhinoconjunctivitis: a randomized controlled trial. Clin Exp Allergy. 2002 Apr;32(4):507-14.

 

63. Pajno GB, Morabito L, Barberio G, Parmiani S. Clinical and immunologic effects of long-term sublingual immunotherapy in asthmatic children sensitized to mites: a double-blind, placebo-controlled study. Allergy. 2000 Sep;55(9):842-9.

 

64. Guez S, Vatrinet C, Fadel R, Andre C. House-dust-mite sublingual-swallow immunotherapy (SLIT) in perennial rhinitis:a double-blind, placebo-controlled study. Allergy. 2000 Apr;55(4):369-75.